Journal article

Early T-BET Expression Ensures an Appropriate CD8( ) Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection

Julia E Prier, Jasmine Li, Linden J Gearing, Moshe Olshansky, Xavier YX Sng, Paul J Hertzog, Stephen J Turner

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2019

Abstract

Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of effector and memory T cells that are then critical for immune clearance. The T-BOX family of transcription factors (TFs) are known to play a key role in T cell differentiation, with mice deficient for the TF T-BET (encoded by Tbx21) unable to generate optimal virus-specific effector responses. Although the importance of T-BET in directing optimal virus-specific T cell responses is accepted, the precise timing and molecular mechanism of action remains unclear. Using a mouse model of influenza A virus infection, we demonstrate that although T-BET is not required for ..

View full abstract