Conference Proceedings
Interactions between genetic predictors of gene expression and dietary factors associated with risk of colorectal cancer
Paneen S Petersen, Yu-Ru Su, Sonja I Berndt, Stephanie A Bien, Hermann Brenner, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Jane C Figueiredo, Steven J Gallinger, Robert W Haile, Tabitha A Harrison, Michael Hoffmeister, Mark A Jenkins, Amit D Joshi, Sebastien Kury, Loic Le Marchand, Yi Lin, Noralane M Lindor, Polly A Newcomb Show all
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2018
Abstract
Abstract Genome-wide association studies of colorectal cancer (CRC) have identified over 50 susceptibility loci. These variants represent only a small fraction of total heritability for CRC. Gene-environment (GxE) interaction studies may help identify novel loci and biological interactions that give insight to the pathogenesis of CRC. Previous genome-wide GxE studies with dietary factors have identified interactions between loci and processed meat consumption and alcohol; however, limited statistical power remains a primary concern. Set-based SNP testing has the potential to increase statistical power to detect GxE interactions by aggregating functionally relevant SNPs. In thi..
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