Chlorhexidine-alcohol versus iodineealcohol for surgical site skin preparation in an elective arthroplasty (ACAISA) study: a cluster randomized controlled trial

TN Peel; MM Dowsey; KL Buising; AC Cheng; PFM Choong

Journal article

Chlorhexidine-alcohol versus iodineealcohol for surgical site skin preparation in an elective arthroplasty (ACAISA) study: a cluster randomized controlled trial

TN Peel, MM Dowsey, KL Buising, AC Cheng, PFM Choong

Clinical Microbiology and Infection | ELSEVIER SCI LTD | Published : 2019

DOI: 10.1016/j.cmi.2019.06.016

Abstract

OBJECTIVES: Surgical site skin preparation is an effective method to prevent wound complications. The optimal agent has not been established, and guidelines contain conflicting recommendations. METHODS: The aim of alcoholic chlorhexidine or alcoholic iodine skin antisepsis (ACAISA) was to assess the efficacy of surgical site skin preparation with 0.5% chlorhexidine gluconate (w/v) in 70% ethanol (v/v) to 1% iodine (w/v) in 70% ethanol (v/v). This was a cluster randomized, controlled, single-centre, assessor-blinded, superiority trial in patients undergoing elective hip or knee arthroplasty. Each surgeon had a set operating day and the unit of randomization was the day of surgery. The primary..

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University of Melbourne Researchers

Peter Choong Author Surgery - St Vincent's Hospital

Kirsty Buising Author Medicine - Royal Melbourne Hospital

Michelle Dowsey Author Surgery - St Vincent's Hospital

Trisha Peel Author Surgery - St Vincent's Hospital

Related Projects (2)

Toward An Evidence-Based Approach For Treating End-Stage Knee Arthritis

World-wide more than one million total knee replacements (TKR) will be performed for end-stage knee osteoarthritis in 2016 alone. With an ag..

Acaisa (Alcoholic Chlorhexidine Or Alcoholic Iodine Skin Antisepsis) Study

The demand for prosthetic joint replacement surgery will double over the next decade. Complications involving the surgical wound are a devas..

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

The authors declare that they have no competing interests. This trial was funded by the National Health and Medical Research Council (NHMRC) of Australia, grant number APP1057736. The funder had no role in the design, data analysis or the preparation of the manuscript. Doctor Trisha Peel is supported by an NHMRC Career Development Fellowship (APP1140350). Associate Professor Michelle Dowsey is supported by a NHMRC Career Development Fellowship (APP1122526). Professor Allen Cheng is supported by a NHMRC Career Development Fellowship (APP1068732). Professor Peter Choong is supported by a NHMRC Practitioner Fellowship (APP1154203).