Journal article
Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study
S Stukas, V Higgins, H Frndova, J Gill, E Hubara, AM Guerguerian, K Boutis, M Beauchamp, C Farrell, FE Babl, C Delzoppo, M Greenham, AA Wilkinson, A Crichton, V Anderson, K Adeli, J Hutchison, C Wellington
Lancet Child and Adolescent Health | ELSEVIER SCI LTD | Published : 2019
Abstract
Background: Traumatic brain injury (TBI) is a major health problem in children. Blood-based biomarkers interpreted by use of normative values might improve the accuracy of diagnosis. Ultrasensitive assays can quantify serum concentrations of the neuronal microtubule-associated protein tau, which is increased in adult brains following TBI. We aimed to determine if serum total tau correlates with TBI diagnosis, severity, and radiological findings on CT scans in children younger than 18 years. Methods: In this case-control study, we included venous blood samples from healthy control children in the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) biobank. For TBI cases,..
View full abstractGrants
Awarded by Ontario Neurotrauma Foundation
Funding Acknowledgements
Canadian Institutes of Health Research, Ontario Neurotrauma Foundation, and Victoria Neurotrauma Foundation