Tissue-Resident Memory T Cells in Cancer Immunosurveillance
Simone L Park, Thomas Gebhardt, Laura K Mackay
TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2019
Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in protecting against viral and bacterial infections is well established. Recent evidence suggests that TRM cells also play a vital part in preventing the development and spread of solid tumors. Here, we discuss the emerging role of TRM cells in anticancer immunity. We highlight defining features of tumor-localizing TRM cells, examine the mechanisms through which they have recently been shown to suppress cancer growth..View full abstract
S.L.P. is supported by a Cancer Council Victoria Postdoctoral Fellowship. T.G. and L.K.M. are Senior Medical Research Fellows supported by the Sylvia and Charles Viertel Charitable Foundation.