Journal article

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Simone L Park, Thomas Gebhardt, Laura K Mackay

TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2019

Abstract

Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in protecting against viral and bacterial infections is well established. Recent evidence suggests that TRM cells also play a vital part in preventing the development and spread of solid tumors. Here, we discuss the emerging role of TRM cells in anticancer immunity. We highlight defining features of tumor-localizing TRM cells, examine the mechanisms through which they have recently been shown to suppress cancer growth..

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