Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease
Shashank Masaldan, Abdel Ali Belaidi, Scott Ayton, Ashley Bush
Pharmaceuticals | MDPI | Published : 2019
Iron dyshomeostasis is a feature of Alzheimer's disease (AD). The impact of iron on AD is attributed to its interactions with the central proteins of AD pathology (amyloid precursor protein and tau) and/or through the iron-mediated generation of prooxidant molecules (e.g., hydroxyl radicals). However, the source of iron accumulation in pathologically relevant regions of the brain and its contribution to AD remains unclear. One likely contributor to iron accumulation is the age-associated increase in tissue-resident senescent cells that drive inflammation and contribute to various pathologies associated with advanced age. Iron accumulation predisposes ageing tissue to oxidative stress that ca..View full abstract
Awarded by Australian National Health and Medical Research Council
Awarded by Alzheimer's Association
Awarded by National Health and Medical Research Council of Australia
Supported by funds from the Australian National Health and Medical Research Council (NHMRC: GNT1159403). Support from the Alzheimer's Association (AARFD-16-442821 to AAB) is gratefully acknowledged. A.I.B. is supported by funds from the National Health and Medical Research Council of Australia (GNT1103703, GNT1101533).