Journal article

Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations

Karel GM Beenakker, Rudi GJ Westendorp, Anton JM de Craen, Sijia Chen, Yotam Raz, Bart EPB Ballieux, Rob GHH Nelissen, Alexander FL Later, Tom W Huizinga, Pieternella E Slagboom, Dorret Boomsma, Andrea B Maier

Journal of Innate Immunity | KARGER | Published : 2020

Abstract

The incidence of bacterial infections and sepsis, as well as the mortality risk from sepsis, is sex specific. These clinical findings have been attributed to sex differences in immune responsiveness. The aim of the present study was to investigate sex differences in monocyte-derived cytokine production response upon stimulation with the gram-negative stimulus lipopolysaccharide (LPS) using cytokine data from 15 study populations. Individual data on ex vivo cytokine production response upon stimulation with LPS in whole blood were available for 4,020 subjects originating from these 15 study populations, either from the general population or from patient populations with specific diseases. Men..

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Grants

Awarded by Seventh Framework Programme MYOAGE


Awarded by Praeventiefonds


Awarded by Dutch Society for Support of Research into Multiple Sclerosis


Awarded by Netherlands Foundation for the Advancements of Tropical Research


Awarded by Netherlands Organization for Scientific Research


Awarded by European Union


Awarded by Netherlands Genomics/Netherlands Organization for Scientific Research, NGI/NWO


Funding Acknowledgements

This study was funded by an unrestricted grant from the Board of Leiden University Medical Center. The included studies were funded by the Seventh Framework Programme MYOAGE, HEALTH-2007-2.4.5-10 (Myoage young study and Myoage old study); the Prof. Dr. Kassenaar Fund and the Praeventiefonds, M.28-2293 (Meningitis relatives study); the Dutch Society for Support of Research into Multiple Sclerosis, 96-229 MS (MS-SLE relatives and MS-SLE); the Netherlands Foundation for the Advancements of Tropical Research, WOTRO 93-467, Stichting Dioraphte, and the Netherlands Organization for Scientific Research, NWO 051-14-050 (Ghana study); the European Union-funded Network of Excellence LifeSpan, FP6 036894 (Ghana study, Leiden 85-plus study); the Netherlands Genomics/Netherlands Organization for Scientific Research, NGI/NWO, 05040202 and 050-060-810 NCHA (LLS and Leiden 85-plus study); Bristol-Myers Squibb, USA (PROSPER study); the Dutch College for Health Insurance Companies and Centocor and Schering-Plough (BEST); and Pfizer Inc., Groton, CT, USA (GARP study).