Journal article

A new strategy for vascular complications in young people with type 1 diabetes mellitus

M Loredana Marcovecchio, R Neil Dalton, Denis Daneman, John Deanfield, Timothy W Jones, Andrew W Neil, David B Dunger, C Acerini, F Ackland, B Anand, T Barrett, V Birrell, F Campbell, M Charakida, T Cheetham, T Chiesa, J Deanfield, C Cooper, I Doughty, A Dutta Show all

NATURE REVIEWS ENDOCRINOLOGY | NATURE PORTFOLIO | Published : 2019

Abstract

Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA1c levels are major risk factors for the development of vascular complications. HbA1c levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Thus, a clear need exists for improved biomarkers to identify high-risk young people early and to develop new intervention strategies. Evidence is accumulating that early increases in urinary albumin excretion could be predicti..

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University of Melbourne Researchers

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Funding Acknowledgements

The authors acknowledge the support of Diabetes UK, the Juvenile Diabetes Research Foundation (JDRF), the British Heart Foundation, the JDRF-Canadian Clinical Trial Network (CCTN), the Canadian Diabetes Association and the Heart and Stroke Foundation Canada, which all contributed funding for the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) studies. The authors thank the members of the AdDIT study group. In the UK, C. Acerini (University of Cambridge, Cambridge, UK), F. Ackland (Northampton General Hospital, Northampton, UK), B. Anand (West Suffolk Hospital, NHS Foundation Trust, Bury St Edmunds, UK), T. Barrett (Birmingham Children's Hospital and University of Birmingham, Birmingham, UK), V. Birrell (James Cook Hospital, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK), F. Campbell (Leeds General Infirmary, The Leeds Teaching Hospitals NHS Trust, Leeds, UK), M. Charakida (King's College London, London, UK), T. Cheetham (Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK), T. Chiesa (University College London, London, UK), J. Deanfield (University College London, London, UK), C. Cooper (Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, UK), I. Doughty (Royal Manchester Children's Hospital, Manchester, UK), A. Dutta (Stoke Mandeville Hospital, Aylesbury, UK), J. Edge (John Radcliffe Hospital, Oxford, UK), A. Gray (University of Oxford, Oxford, UK), J. Hamilton-Shield (University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, UK), N. Mann (Royal Berkshire Hospital, Reading, UK), M. L. Marcovecchio (University of Cambridge, Cambridge, UK), S. Marshall (Newcastle University, Newcastle upon Tyne, UK), G. Rayman (Ipswich Hospitals NHS Trust, Ipswich, UK), J. M. Robinson (Royal Albert Edward Infirmary, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UK), M. Russell-Taylor (Wycombe Hospital, Buckingham Healthcare NHS Trust, High Wycombe, UK), V. Sankar (Royal Bolton Hospital, Bolton NHS Foundation Trust, Bolton, UK), A. Smith (Northampton General Hospital, Northampton, UK), N. Thalange (Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK) and C. Yaliwal (Royal Berkshire Hospital, Reading, UK). In Australia, P. Benitez-Aguirre (The Children's Hospital at Westmead and University of Sydney, Sydney, New South Wales, Australia), F. Cameron (Royal Children's Hospital, Murdoch Children's Research Institute and the University of Melbourne, Melbourne, Victoria, Australia), A. Cotterill (University of Queensland, Brisbane, Queensland, Australia), J. Couper (Women's and Children's Hospital and University of Adelaide, Adelaide, South Australia, Australia), M. Craig (The Children's Hospital at Westmead, University of Sydney, and University of New South Wales, Sydney, New South Wales, Australia), E. Davis (Princess Margaret Hospital for Children and University of Western Australia, Perth, Western Australia, Australia), K. Donaghue (The Children's Hospital at Westmead and University of Sydney, Sydney, New South Wales, Australia), T. W. Jones (Princess Margaret Hospital for Children and University of Western Australia, Perth, Western Australia, Australia), B. King (University of Newcastle, Newcastle, New South Wales, Australia), C. Verge (Sydney Children's Hospital and University of New South Wales, Sydney, New South Wales, Australia), P. Bergman (Monash Children's Hospital, Clayton, Victoria, Australia) and C. Rodda (University of Melbourne, Melbourne, Victoria, Australia). In Canada, C. Clarson (London Health Sciences Centre and Western University, London, Ontario, Canada), J. Curtis (The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada), D. Daneman (The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada), F. Mahmud (The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada) and E. Sochett (The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada).