Journal article

A systematic review of risk-reducing cancer surgery outcomes for hereditary cancer syndromes

Oliver Peacock, Peadar S Waters, Jaime Otero de Pablos, Alex Boussioutas, Anita Skandarajah, Jonathan A Simpson, Satish K Warrier, Alexander G Heriot

European Journal of Surgical Oncology | ELSEVIER SCI LTD | Published : 2019

Abstract

Cancer predisposition genes are rare mutations that confer a high risk of cancer. For many hereditary cancer syndromes, risk reducing surgery is the single most effective strategy for preventing cancer, but it is irreversible. It has recently attracted significant media attention, following celebrity endorsement, which has led to a perceived lack of ill-effect and guaranteed successful outcome by the general public. Given these high expectations for risk-reducing surgery, a systematic review was performed to evaluate the reported complications for patients undergoing risk-reducing surgery. A systematic review of MEDLINE, EMBASE, CINAHL, AMED and PubMed work was conducted using PRISMA for ris..

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