Glucose Control in Adults with Type 1 Diabetes Using a Medtronic Prototype Enhanced-Hybrid Closed-Loop System: A Feasibility Study

MH Lee; S Vogrin; B Paldus; HM Jones; V Obeyesekere; C Sims; SA Wyatt; GM Ward; SA McAuley; RJ MacIsaac; B Krishnamurthy; V Sundararajan; AJ Jenkins; DN O'Neal

Journal article

Glucose Control in Adults with Type 1 Diabetes Using a Medtronic Prototype Enhanced-Hybrid Closed-Loop System: A Feasibility Study

MH Lee, S Vogrin, B Paldus, HM Jones, V Obeyesekere, C Sims, SA Wyatt, GM Ward, SA McAuley, RJ MacIsaac, B Krishnamurthy, V Sundararajan, AJ Jenkins, DN O'Neal

Diabetes Technology and Therapeutics | MARY ANN LIEBERT, INC | Published : 2019

DOI: 10.1089/dia.2019.0120

Abstract

Background: Experience from first-generation closed-loop (CL) systems informs refinements to enhance glucose control and user acceptance. A next-generation prototype enhanced-hybrid CL (E-HCL) system incorporates iterative changes to the Medtronic MiniMed 670G CL system, including automated correction boluses, lower target glucose level, and user enhancements. The aim was to explore safety, system performance, and glucose control using E-HCL in adults with type 1 diabetes. Methods: Twelve adults underwent this first in-human feasibility study. After a 1-week run-in using open-loop (OL), E-HCL was activated at the start of a supervised 1-week hotel phase, followed by 3 weeks free living at ho..

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University of Melbourne Researchers

Sara Vogrin Author

Barbora Paldus Author

Glenn Ward Author

Sybil McAuley Author

Grants

Funding Acknowledgements

This investigator-initiated study was supported by a grant from Medtronic. M.H.L. is supported by an NHMRC Postgraduate Scholarship, co-funded by Diabetes Australia. B.P. is supported by a University of Melbourne Scholarship and research support from JDRF. S.A.M. is supported by a JDRF Early-Career Diabetes Research Award. A.J.J. is supported by an NHMRC Practitioner Grant and is a Sydney Medical Foundation Fellow.