Journal article

Assessment of airway response distribution and paradoxical airway dilation in mice during methacholine challenge

S Dubsky, GR Zosky, K Perks, CR Samarage, Y Henon, SB Hooper, A Fouras

JOURNAL OF APPLIED PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2017

Abstract

Detailed information on the distribution of airway diameters during bronchoconstriction in situ is required to understand the regional response of the lungs. Imaging studies using computed tomography (CT) have previously measured airway diameters and changes in response to bronchoconstricting agents, but the manual measurements used have severely limited the number of airways measured per subject. Hence, the detailed distribution and heterogeneity of airway responses are unknown. We have developed and applied dynamic imaging and advanced image-processing methods to quantify and compare hundreds of airways in vivo. The method, based on CT, was applied to house dust-mite-sensitized and control..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Japan Synchrotron Radiation Research Institute (JASRI)


Awarded by Australian Research Council


Funding Acknowledgements

Support for A. Fouras was provided by the National Health and Medical Research Council Career Development Fellowship (APP1022721). The project was supported by an American Asthma Foundation research grant, the Japan Synchrotron Radiation Research Institute (JASRI; 2012B1100), and the Multimodal Australian ScienceS Imaging and Visualisation Environment (MASSIVE; https://www.massive.org.au/), Australian Research Council (DP150102240).