Genetic absence epilepsy: Effective connectivity from piriform cortex to mediodorsal thalamus
James C Young, Antonio G Paolini, Mangor Pedersen, Graeme D Jackson
EPILEPSY & BEHAVIOR | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019
OBJECTIVE: The objective of the study was to quantify effective connectivity from the piriform cortex to mediodorsal thalamus, in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). METHODS: Local field potentials (LFPs) were recorded using microelectrode arrays implanted in the mediodorsal thalamus and piriform cortex, in three urethane anesthetized GAERS and three control rats. Screw electrodes were placed in the primary motor cortex to identify epileptiform discharges. We used transfer entropy to measure effective connectivity from piriform cortex to mediodorsal thalamus prior to and during generalized epileptiform discharges. RESULTS: We observed increased theta band effective connect..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
We thank Angela Lim for assistance in electrophysiology recording monitoring and aiding in transcardial perfusion and Dr. Helen Nasser for her assistance with performing histology. We also acknowledge Prof. Terence O'Brien and Dr. Pablo Casilla-Espinosa for providing GAERS and NEC rats for this study. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government in particular the funding from the Operational Infrastructure Support Grant. This study was supported by the National Health and Medical Research Council of Australia (NHMRC Project Grant 1091593). James C Young acknowledges that they have been supported through an Australian Government Research Training Program Scholarship.