Journal article

Multiunit cluster firing patterns of piriform cortex and mediodorsal thalamus in absence epilepsy

James C Young, Helen M Nasser, Pablo M Casillas-Espinosa, Terence J O'Brien, Graeme D Jackson, Antonio G Paolini

Epilepsy & Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

OBJECTIVE: The objective of the study were to investigate patterns of multiunit cluster firing in the piriform cortex (PC) and mediodorsal thalamus (MDT) in a rat model of genetic generalized epilepsy (GGE) with absence seizures and to assess whether these regions contribute to the initiation or spread of generalized epileptiform discharges. METHODS: Multiunit clusters and their corresponding local field potentials (LFPs) were recorded from microelectrode arrays implanted in the PC and MDT in urethane anesthetized Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and nonepileptic control (NEC) rats. Peristimulus time histograms (PSTHs) and cross-correlograms were used to observe transien..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Peter Doherty Early Career Fellowship (NHMRC)


Funding Acknowledgements

We thank Angela Lim for assistance in electrophysiology recording monitoring and aiding in transcardial perfusion. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government in particular the funding from the Operational Infrastructure Support Grant. This study was supported by the National Health and Medical Research Council of Australia (NHMRC Project Grant #1091593 and NHMRC Program Grant #1091593). James C Young acknowledges that they have been supported through an Australian Government Research Training Program Scholarship. Pablo Casillas-Espinosa works is funded by the Peter Doherty Early Career Fellowship (NHMRC#APP1166170).