Journal article

The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

Rohann JM Correa, Alexander Louie, Nicholas G Zaorsky, Eric J Lehrer, Rodney Ellis, Lee Ponsky, Irving Kaplan, Anand Mahadevan, William Chu, Anand Swaminath, Raquibul Hannan, Hiroshi Onishi, Bin S Teh, Alexander Muacevic, Simon S Lo, Michael Staehler, Shankar Siva

European Urology Focus | ELSEVIER | Published : 2019

Abstract

CONTEXT: Stereotactic ablative radiotherapy (SABR) is an emerging treatment option for primary renal cell carcinoma (RCC). OBJECTIVE: To systematically review the literature on SABR for primary RCC and perform a meta-analysis evaluating local control (LC), toxicity, and renal function. EVIDENCE ACQUISITION: A PROSPERO-registered (#115573), Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA)-based systematic review of the literature was conducted (1995-2019). Studies of SABR targeting primary RCC tumors were included, while those targeting only metastases were excluded. The primary outcome was LC defined as tumor size reduction and/or absence of local progression. Secon..

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