Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study

J Bartoszko; KE Thorpe; A Laupacis; DN Wijeysundera; PS Myles; MA Shulman; S Wallace; C Farrington; B Thompson; M Ellis; B Borg; RK Kerridge; J Douglas; J Brannan; J Pretto; MG Godsall; N Beauchamp; S Allen; A Kennedy; E Wright; J Malherbe; H Ismail; B Riedel; A Melville; H Sivakumar; A Murmane; K Kenchington; Y Kirabiyik; U Gurunathan; C Stonell; K Brunello; K Steele; O Tronstad; P Masel; A Dent; E Smith; A Bodger; M Abolfathi; P Sivalingam; A Hall; TW Painter; S Macklin; A Elliott; AM Carrera; NCS Terblanche; S Pitt; J Samuels; C Wilde; K Leslie; A MacCormick; D Bramley; AM Southcott; J Grant; H Taylor; S Bates; M Towns; A Tippett; F Marshall; CD Mazer; J Kunasingam; A Yagnik; C Crescini; S Yagnik; CJL McCartney; S Choi; P Somascanthan; K Flores; WS Beattie; K Karkouti; HA Clarke; A Jerath; SA McCluskey; M Wasowicz; JT Granton; L Day; J Pazmino-Canizares; P Oh; R Belliard; L Lee; K Dobson; V Chan; R Brull; N Ami; M Stanbrook; K Hagen; D Campbell; T Short; J Van Der Westhuizen; K Higgie; H Lindsay; R Jang; C Wong; D Mcallister; M Ali; J Kumar; E Waymouth; C Kim; J Dimech; M Lorimer; J Tai

Journal article

Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study

J Bartoszko, KE Thorpe, A Laupacis, DN Wijeysundera, PS Myles, MA Shulman, S Wallace, C Farrington, B Thompson, M Ellis, B Borg, RK Kerridge, J Douglas, J Brannan, J Pretto, MG Godsall, N Beauchamp, S Allen, A Kennedy, E Wright Show all

British Journal of Anaesthesia | ELSEVIER SCI LTD | Published : 2019

DOI: 10.1016/j.bja.2019.04.058

Abstract

Background: Preoperative anaemia is associated with elevated risks of postoperative complications. This association may be explained by confounding related to poor cardiopulmonary fitness. We conducted a pre-specified substudy of the Measurement of Exercise Tolerance before Surgery (METS) study to examine the associations of preoperative haemoglobin concentration with preoperative cardiopulmonary exercise testing performance (peak oxygen consumption, anaerobic threshold) and postoperative complications. Methods: The substudy included a nested cross-sectional analysis and nested cohort analysis. In the cross-sectional study (1279 participants), multivariate linear regression modelling was use..

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University of Melbourne Researchers

Hilmy Ismail Author

Bernhard Riedel Author

Kate Leslie Author

Ann Marie Southcott Author

Grants

Funding Acknowledgements

The METS study was supported by grants from the Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; Ontario Ministry of Health and Long-Term Care; Ontario Ministry of Research, Innovation and Science; United Kingdom (UK) National Institute of Academic Anaesthesia; UK Clinical Research Collaboration; Australian and New Zealand College of Anaesthetists; and Monash University (Melbourne, Victoria, Australia). These sponsors had no role in the design and conduct of the METS study; collection, management, analysis and interpretation of the data; preparation, review or approval of this paper; and decision to submit this manuscript for publication. ProfessorWijeysundera is supported in part by a New Investigator Award from the Canadian Institutes of Health Research, an Excellence in Research Award from the Department of Anesthesia at the University of Toronto, and the Endowed Chair in Translational Anesthesiology Research at St. Michael's Hospital and University of Toronto. Professor Laupacis is supported in part by a Canada Research Chair in Health Policy and Citizen Engagement from the Government of Canada.