Journal article

Petchiether A attenuates obstructive nephropathy by suppressing TGF-ss/Smad3 and NF-kappa B signalling

Yong-Ke You, Qi Luo, Wei-Feng Wu, Jiao-Jiao Zhang, Hong-Jian Zhu, Lixing Lao, Hui Y Lan, Hai-Yong Chen, Yong-Xian Cheng

Journal of Cellular and Molecular Medicine | WILEY | Published : 2019

Abstract

Obstructive nephropathy is the end result of a variety of diseases that block drainage from the kidney(s). Transforming growth factor-β1 (TGF-β1)/Smad3-driven renal fibrosis is the common pathogenesis of obstructive nephropathy. In this study, we identified petchiether A (petA), a novel small-molecule meroterpenoid from Ganoderma, as a potential inhibitor of TGF-β1-induced Smad3 phosphorylation. The obstructive nephropathy was induced by unilateral ureteral obstruction (UUO) in mice. Mice received an intraperitoneal injection of petA/vehicle before and after UUO or sham operation. An in vivo study revealed that petA protected against renal inflammation and fibrosis by reducing the infiltrati..

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Grants

Awarded by National Science Fund for Distinguished Young Scholars


Awarded by Shenzhen Science & Innovation Fund


Awarded by National Natural Science Foundation of China


Awarded by NSFC-Joint Foundation of Yunnan Province


Awarded by Seed Fund for Basic Research from the University of Hong Kong


Funding Acknowledgements

This study was supported by the National Science Fund for Distinguished Young Scholars (81525026 to YXC), Shenzhen Science & Innovation Fund (JCYJ20180306173745092 to HYC), the National Natural Science Foundation of China (21472199 to YXC), the NSFC-Joint Foundation of Yunnan Province (U1702287 to YXC), and the Seed Fund for Basic Research from the University of Hong Kong (Grant No. 201411159149 to HYC, 201611159209).