Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.
Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin
Journal of Controlled Release | Elsevier | Published : 2019
Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highly selective. Determination of the affinity between cell lines and nanoparticles is thus of central importance, both to enable comparison of particles and to facilitate prediction of in vivo response. Attempts to compare particle performance can be dominated by experimental artifacts (including settling effects) or variability in experimental protocol. Instead, qualitative methods are generally used, limiting the reusability of many studies. Herein, we introduce a mathematical model-based approach to quantify the affinity between a cell-particle pairing, independen..View full abstract
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Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). FC acknowledges the award of an NHMRC Senior Principal Research Fellowship (GNT1135806). MB acknowledges support from H2020/European Commission through a Marie Skłodowska-Curie Individual Fellowship under grant agreement no. 745676.