Journal article

Genetically Determined Risk of Depression and Functional Outcome After Ischemic Stroke: Mendelian Randomization Study

Dipender Gill, Nicole E James, Grace Monori, Erik Lorentzen, Israel Fernandez-Cadenas, Robin Lemmens, Vincent Thijs, Natalia S Rost, Rodney Scott, Graeme J Hankey, Arne Lindgren, Christina Jern, Jane M Maguire

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

Background and Purpose- Psychosocial factors can have implications for ischemic stroke risk and recovery. This study investigated the effect of genetically determined risk of depression on these outcomes using the Mendelian randomization (MR) framework. Methods- Genetic instruments for risk of depression were identified in a discovery genome-wide association study of 246 363 cases and 561 190 controls and further replicated in a separate population of 474 574 cases and 1 032 579 controls. Corresponding genetic association estimates for risk of ischemic stroke were taken from 60 341 cases and 454 450 controls, with those for functional outcome 3 months after ischemic stroke taken from an anal..

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Grants

Awarded by National Institutes of Health-National Institute of Neurological Disorders and Stroke


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

Dr Gill is supported by the Wellcome 4i Programme at Imperial College London. Dr Rost is, in part, supported by National Institutes of Health-National Institute of Neurological Disorders and Stroke grants R01NS086905 and R01NS082285. Dr Scott is supported by the National Health and Medical Research Council. Dr Lindgren is supported by Lund University, Skane University Hospital, the Freemasons Lodge of Instruction Eos in Lund, the Swedish Stroke Association, and Sparbanksstiftelsen Fars och Frosta. Dr Jern is supported by the Swedish Heart and Lung Foundation and the Swedish Medical Research Council.