Journal article

Investigation of Nicotianamine and 2 ' Deoxymugineic Acid as Enhancers of Iron Bioavailability in Caco-2 Cells

Jesse T Beasley, Jonathan J Hart, Elad Tako, Raymond P Glahn, Alexander AT Johnson

Nutrients | MDPI | Published : 2019

Abstract

Nicotianamine (NA) is a low-molecular weight metal chelator in plants with high affinity for ferrous iron (Fe2+) and other divalent metal cations. In graminaceous plant species, NA serves as the biosynthetic precursor to 2' deoxymugineic acid (DMA), a root-secreted mugineic acid family phytosiderophore that chelates ferric iron (Fe3+) in the rhizosphere for subsequent uptake by the plant. Previous studies have flagged NA and/or DMA as enhancers of Fe bioavailability in cereal grain although the extent of this promotion has not been quantified. In this study, we utilized the Caco-2 cell system to compare NA and DMA to two known enhancers of Fe bioavailability-epicatechin (Epi) and ascorbic ac..

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