Journal article

Detection and localisation of primary prostate cancer using (68)gallium prostate-specific membrane antigen positron emission tomography/computed tomography compared with multiparametric magnetic resonance imaging and radical prostatectomy specimen pathology

Arveen A Kalapara, Tatenda Nzenza, Henry YC Pan, Zita Ballok, Shakher Ramdave, Richard O'Sullivan, Andrew Ryan, Martin Cherk, Michael S Hofman, Badrinath R Konety, Nathan Lawrentschuk, Damien Bolton, Declan G Murphy, Jeremy P Grummet, Mark Frydenberg

BJU INTERNATIONAL | WILEY | Published : 2020

Abstract

OBJECTIVE: To compare the accuracy of 68 gallium prostate-specific membrane antigen positron emission tomography/computed tomography (68 Ga-PSMA PET/CT) with multiparametric MRI (mpMRI) in detecting and localising primary prostate cancer when compared with radical prostatectomy (RP) specimen pathology. PATIENTS AND METHODS: Retrospective review of men who underwent 68 Ga-PSMA PET/CT and mpMRI for primary prostate cancer before RP across four centres between 2015 and 2018. Patients undergoing imaging for recurrent disease or before non-surgical treatment were excluded. We defined pathological index tumour as the lesion with highest International Society of Urological Pathology Grade Group (GG..

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