Pneumococcal carriage, density, and co-colonization dynamics: A longitudinal study in Indonesian infants
Chrysanti Murad, Eileen M Dunne, Sunaryati Sudigdoadi, Eddy Fadlyana, Rodman Tarigan, Casey L Pell, Emma Watts, Cattram D Nguyen, Catherine Satzke, Jason Hinds, Mia Milanti Dewi, Meita Dhamayanti, Nanan Sekarwana, Kusnandi Rusmil, E Kim Mulholland, Cissy Kartasasmita
International Journal of Infectious Diseases | ELSEVIER SCI LTD | Published : 2019
OBJECTIVES: Nasopharyngeal carriage of Streptococcus pneumoniae underpins disease development and transmission. This study was performed to examine pneumococcal carriage dynamics, including density and multiple serotype carriage, in Indonesian infants during the first year of life. METHODS: Two hundred healthy infants were enrolled at 2 months of age. Eight nasopharyngeal swabs were collected from enrolment until 12 months of age. Pneumococci were detected using quantitative PCR and serotyped by microarray. Regression models assessed factors influencing pneumococcal carriage and density. RESULTS: Eighty-five percent of infants carried pneumococci at least once during the study. The median ag..View full abstract
This study was funded by PATH. PATH contributed to the study design but had no involvement in the data collection, data analysis, writing, or decision to publish. Murdoch Children's Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program.