Journal article

Pneumococcal carriage, density, and co-colonization dynamics: A longitudinal study in Indonesian infants

Chrysanti Murad, Eileen M Dunne, Sunaryati Sudigdoadi, Eddy Fadlyana, Rodman Tarigan, Casey L Pell, Emma Watts, Cattram D Nguyen, Catherine Satzke, Jason Hinds, Mia Milanti Dewi, Meita Dhamayanti, Nanan Sekarwana, Kusnandi Rusmil, E Kim Mulholland, Cissy Kartasasmita

International Journal of Infectious Diseases | ELSEVIER SCI LTD | Published : 2019

Abstract

OBJECTIVES: Nasopharyngeal carriage of Streptococcus pneumoniae underpins disease development and transmission. This study was performed to examine pneumococcal carriage dynamics, including density and multiple serotype carriage, in Indonesian infants during the first year of life. METHODS: Two hundred healthy infants were enrolled at 2 months of age. Eight nasopharyngeal swabs were collected from enrolment until 12 months of age. Pneumococci were detected using quantitative PCR and serotyped by microarray. Regression models assessed factors influencing pneumococcal carriage and density. RESULTS: Eighty-five percent of infants carried pneumococci at least once during the study. The median ag..

View full abstract