Journal article

Neurohumoral interactions contributing to renal vasoconstriction and decreased renal blood flow in heart failure

Rohit Ramchandra, Daniel T Xing, Marcus Matear, Gavin Lambert, Andrew M Allen, G Clive N May

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2019

Abstract

In heart failure (HF), increases in renal sympathetic nerve activity (RSNA), renal norepinephrine spillover, and renin release cause renal vasoconstriction, which may contribute to the cardiorenal syndrome. To increase our understanding of the mechanisms causing renal vasoconstriction in HF, we investigated the interactions between the increased activity of the renal nerves and the renal release of norepinephrine and renin in an ovine pacing-induced model of HF compared with healthy sheep. In addition, we determined the level of renal angiotensin type-1 receptors and the renal vascular responsiveness to stimulation of the renal nerves and α1-adrenoceptors. In conscious sheep with mild HF (ej..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC Research Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia Grant 1020783 and by the Victorian Government through the Operational Infrastructure Scheme. R. Ramchandra was the recipient of an NHMRC/National Heart Foundation-funded Career Development Fellowship, and C. N. May was supported by an NHMRC Research Fellowship 566819).