Journal article

Metabolomics: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Susan Ellul, Melissa Wake, Susan A Clifford, Katherine Lange, Peter Wurtz, Markus Juonala, Terence Dwyer, John B Carlin, David P Burgner, Richard Saffery

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVES: Nuclear magnetic resonance (NMR) metabolomics is high throughput and cost-effective, with the potential to improve the understanding of disease and risk. We examine the circulating metabolic profile by quantitative NMR metabolomics of a sample of Australian 11-12 year olds children and their parents, describe differences by age and sex, and explore the correlation of metabolites in parent-child dyads. DESIGN: The population-based cross-sectional Child Health CheckPoint study nested within the Longitudinal Study of Australian Children. SETTING: Blood samples collected from CheckPoint participants at assessment centres in seven Australian cities and eight regional towns; February 2..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC Senior Research Fellowships


Awarded by Honorary Future Leader Fellowship of the National Heart Foundation of Australia


Awarded by Academy of Finland


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grants 1041352, 1109355), The Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute (MCRI), The University of Melbourne, the National Heart Foundation of Australia (100660) and the Financial Markets Foundation for Children (2014-055, 2016-310). NHMRC Senior Research Fellowships supported MW (1046518), DPB (1064629) and RS (1045161). MW was supported by Cure Kids New Zealand and DPB holds an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (100369). PW is supported by Academy of Finland (grant numbers 312476 and 312477). The MCRI administered the research grants for the study and provided infrastructural support (IT and biospecimen management) to its staff and the study, but played no role in the conduct or analysis of the trial. DSS played a role in study design; however, no other funding bodies had a role in the study design and conduct; data collection, management, analysis, and interpretation; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Research at the MCRI is supported by the Victorian Government's Operational Infrastructure Support Program.