Journal article

Botulinum Toxin in the Management of Children with Cerebral Palsy

Iqbal Multani, Jamil Manji, Tandy Hastings-Ison, Abhay Khot, Kerr Graham

PEDIATRIC DRUGS | ADIS INT LTD | Published : 2019

Abstract

During the past 25 years, botulinum toxin type A (BoNT-A) has become the most widely used medical intervention in children with cerebral palsy. In this review we consider the gaps in our knowledge in the use of BoNT-A and reasons why muscle morphology and function in children with cerebral palsy are impaired. We review limitations in our knowledge regarding the mechanisms underlying the development of contractures and the difficulty in preventing them. It is clear from this review that injection of BoNT-A in the large muscles of both the upper and lower limbs of children with cerebral palsy will result in a predictable decrease in muscle activity, which is usually reported as a reduction in ..

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