Journal article

An integrated transcriptional switch at the beta-selection checkpoint determines T cell survival, development and leukaemogenesis

Anchi S Chann, Sarah M Russell

Biochemical Society Transactions | PORTLAND PRESS LTD | Published : 2019

Abstract

In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here, we review how transcriptional regulation coordinates fate determination in early T cell development to enable β-selection. Errors in this transcription control can trigger T cell acute lymphoblastic leukaemia. We describe how the β-selection checkpoint goes awry in leukaemic transformation.