An integrated transcriptional switch at the beta-selection checkpoint determines T cell survival, development and leukaemogenesis
Anchi S Chann, Sarah M Russell
Biochemical Society Transactions | PORTLAND PRESS LTD | Published : 2019
In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here, we review how transcriptional regulation coordinates fate determination in early T cell development to enable β-selection. Errors in this transcription control can trigger T cell acute lymphoblastic leukaemia. We describe how the β-selection checkpoint goes awry in leukaemic transformation.
Awarded by Australian National Health and Medical Research Council
A. C. is supported by Swinburne University Postgraduate Research Award PhD. Scholarship. S. R. is supported by an Australian National Health and Medical Research Council Project Grant (APP1099140).