Journal article

Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity

Nicholas C Sinclair, Hugh J McDermott, James B Fallon, Thushara Perera, Peter Brown, Kristian J Bulluss, Wesley Thevathasan

Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

Deep brain stimulation is an established therapy for Parkinson's disease; however, its effectiveness is hindered by limited understanding of therapeutic mechanisms and the lack of a robust feedback signal for tailoring stimulation. We recently reported that subthalamic nucleus deep brain stimulation evokes a neural response resembling a decaying high-frequency (200-500 Hz) oscillation that typically has a duration of at least 10 ms and is localizable to the dorsal sub-region. As the morphology of this response suggests a propensity for the underlying neural circuitry to oscillate at a particular frequency, we have named it evoked resonant neural activity. Here, we determine whether this evok..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

This work was supported by the Colonial Foundation, St Vincent's Hospital Research Endowment Fund, and the National Health and Medical Research Council [project grant #1103238]. The Bionics Institute acknowledges the support it receives from the Victorian Government through its operational infrastructure program. N.C.S. is supported through an Australian Government Research Training Program Scholarship. P.B. is supported by the Medical Research Council of Great Britain. W.T is supported by Lions International and the National Health and Medical Research Council.