Journal article

Oxidative stress, inflammation and risk of neurodegeneration in a population sample

N Cherbuin, E Walsh, BT Baune, KJ Anstey

European Journal of Neurology | WILEY | Published : 2019


BACKGROUND AND PURPOSE: Inflammation and oxidative stress (OS) have been clearly linked to neurodegeneration. However, studies investigating the associations between peripheral markers of inflammation and cognitive decline have produced mixed results. This is possibly due to the fact that markers are typically tested individually despite the fact that biologically they function interactively. Thus, the aim of this study was to investigate the association between a combination of OS/inflammation markers and outcomes including mild cognitive impairment (MCI) diagnosis, cognitive decline and hippocampal atrophy. METHODS: Oxidative stress/inflammation status was assessed in 380 older community-l..

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University of Melbourne Researchers