Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: A systematic review and meta-analysis of individual participant data

Grants

Funding Acknowledgements

The Sydney Memory and Ageing Study was supported by the National Health and Medical Research Council (NHMRC; grants 350833, 510175, and 510124) and the Australian Research Council (DP0774213, DP0773584, and LP0669645). The Health, Well-Being, and Aging Study - Brazil was supported by the Foundation of Research Support of Sao Paulo (FAPESP; grants 1999/05125-7, 2005/54947-2, and 2009/53778-3). The Intervention Project on Cerebrovascular Diseases and Dementia in the Ebersberg District was supported by the Allgemeine Ortskrankenkasse Bayern, the German Stroke Foundation, Bayer Vital GmbH, Berlin-Chemie AG, Organon Pharmaceuticals, Ratiopharm GmbH, Sanofi Synthelabo GmbH, and Teva Pharmaceutical Industries Ltd. The Mr Os and Ms Os Study was supported by The Hong Kong Jockey Club Charities Trust and The SH Ho Centre for Gerontology and Geriatrics. The Singapore Longitudinal Ageing Studies were sponsored by the Biomedical Research Council (grants 03/1/21/17/214 and 08/1/21/19/567). The Hertfordshire Cohort Study was sponsored by the Medical Research Council UK. The Hong Kong Old-Old Study was sponsored by the Croucher Foundation and Hong Kong Health Services Research (grant 411009). The Health in Men Study was sponsored by the National Health and Medical Research Council (grants 279408, 379600, 403963, 513823, 540403, 540504, 540405, 634492, 1021416, 1045710, and 1060557). The Canadian Study of Health and Aging was initially funded through the Canadian federal government's Seniors' Independence Research Program (1998). The program funds were administered by the National Health Research and Development Program of Health Canada. Supplementary funding was administered by the Medical Research Council of Canada. After 1998, funding for the core study was obtained from the Canadian Institutes for Health Research (grant MOP-42530) and supplementary funding for the caregiver component was provided under grant MOP-43945. Throughout the study, additional funding was obtained for supplementary components and for personnel funding from provincial governments, research granting agencies, and the private sector. Funding from the pharmaceutical industry contributed to the collection and analysis of biological samples, to the caregiver substudy, to personnel support via training awards, and access to provincial health care plan data. Support was also provided by the Pfizer Corporation Inc, Bayer Canada Inc, Janssen-Ortho Inc, and Merck Frosst Canada & Co. The study was coordinated through the University of Ottawa, which provided administrative support and facilities for the coordinating center, and the Division of Aging and Seniors, Health Canada. The Insufficienza Cardiaca negli Anziani Residenti a Dicomano study was funded by Regione Toscana. The Selenium and Cognitive Decline Study was supported by the National Institutes of Health/National Institute on Aging (grant R01 AG019181). The BELFRAIL study (B40320084685) is funded by an unconditional grant from Fondation Louvain. Fondation Louvain is the support-group unit of the Universite Catholique de Louvain, which is in charge of developing education and research projects for the university by collecting gifts from corporations, foundations, and alumni. The Treviso Longeva study was supported by Regione del Veneto (grant DGR 13/12/2002, 3604, project number 76), Fondazione Cassamarca, Fondazione Veneto Banca, the Province of Treviso, and the Municipality of Treviso. The Study of Osteoporotic Fractures (SOF) is supported by National Institutes of Health funding. The National Institute on Aging (NIA) provides support under grant numbers R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, and R01 AG027576. The Osteoporotic Fractures in Men (MrOS) study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the grant numbers U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128. The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep ancillary study Outcomes of Sleep Disorders in Older Men under the grant numbers R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839. The Einstein Aging Study is supported by the National Institute on Aging (NIA) grant P01 AGO3949. The De Leiden 85-Plus study was supported by several unrestricted grants from the Netherlands Organisation of Scientific Research (ZonMw) and the Ministry of Health, Welfare, and Sports. Dr Eurelings received an Academic Medical Center PhD Scholarship (2011/1190). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. We gratefully acknowledge Francesca Mazzella, MD, PhD (Department of Translational Medical Sciences, Federico II University of Naples and Emergency Department, Antonio Cardarelli Hospital, Naples, Italy) for completing the mortality follow-up for the Osservatorio Geriatrico Regione Campania (OGC) study, Michele Cellurale, MD (Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy) for database management of the OGC study, Pasquale Abete, MD, PhD (Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy) for his contribution to study design and coordination of the OGC study, Graeme J Hankey, MD, FRACP (School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia), Bu B Yeap, MBBS, PhD (School of Medicine and Pharmacology, University of Western Australia, Perth, Australia), Jonathan Golledge, MD, MChir, FRACS, FRCS (Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia) for their contribution to obtain funding and data collection for the Health in Men study; all investigators for the first and second phase of the Canadian Study on Health and Aging (CSHA; listed in http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1486712/pdf/cmaj00286-0095.pdf and http://www.neurology.org/content/55/1/66.full.pdf) for their contribution to study design, data collection, and coordination of the CSHA. The National Registry of Diseases Office of the Health Promotion Board of Singapore is gratefully acknowledged for providing mortality data for the Singapore Longitudinal Ageing Studies. No compensation was received by any individual for contribution to this study.