Journal article

Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data.

Lisa Sm Eurelings, Jan Willem van Dalen, Gerben Ter Riet, Eric P Moll van Charante, Edo Richard, Willem A van Gool, Osvaldo P Almeida, Tiago S Alexandre, Bernhard T Baune, Horst Bickel, Francesco Cacciatore, Cyrus Cooper, Ton Ajm de Craen, Jean-Marie Degryse, Mauro Di Bari, Yeda A Duarte, Liang Feng, Nicola Ferrara, Leon Flicker, Maurizio Gallucci Show all

Clin Epidemiol | Published : 2018


Background: Previous findings suggest that apathy symptoms independently of depressive symptoms measured using the Geriatric Depression Scale (GDS) are associated with cardiovascular disease (CVD) in older individuals. Aims: To study whether apathy and depressive symptoms in older people are associated with future CVD, stroke, and mortality using individual patient-data meta-analysis. Methods: Medline, Embase, and PsycInfo databases up to September 3, 2013, were systematically searched without language restrictions. We sought prospective studies with older (mean age ≥65 years) community-dwelling populations in which the GDS was employed and subsequent stroke and/or CVD were recorded to provi..

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