Journal article

Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Julian Dascalu, Mengjiao Liu, Kate Lycett, Anneke C Grobler, Mingguang He, David P Burgner, Tien Yin Wong, Melissa Wake

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVES: To describe distributions and concordance of retinal microvasculature measurements in a population-based sample of Australian parent-child dyads at child age 11-12 years. DESIGN: Cross-sectional Child Health CheckPoint study, between waves 6 and 7 of the national population-based Longitudinal Study of Australian Children (LSAC). SETTING: Assessment centres in seven Australian cities, February 2015-March 2016. PARTICIPANTS: Of the 1874 participating families, 1288 children (51% girls) and 1264 parents (87% mothers, mean age 43.7) were analysed. Diabetic participants and non-biological pairs were excluded from concordance analyses. OUTCOME MEASURES: Retinal photographs were taken b..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grants 1041352, 1109355), The Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute (MCRI), The University of Melbourne, the National Heart Foundation of Australia (100660) and Financial Markets Foundation for Children (2014-055, 2016-310). The following authors were supported by the NHMRC: Senior Research Fellowships to MW (1046518) and DPB (1064629); Early Career Fellowship to KL (1091124). The following authors were supported by the National Heart Foundation of Australia: Honorary Future Leader Fellowship to DPB (100369); Postdoctoral Fellowship to KL (101239). MW was supported by Cure Kids New Zealand and ML by a Melbourne International Research Scholarship. The MCRI administered the research grants for the study and provided infrastructural support (IT and biospecimen management) to its staff and the study, but played no role in the conduct or analysis of the trial. DSS played a role in study design; however, no other funding bodies had a role in the study design and conduct; data collection, management, analysis and interpretation; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication. Research at the MCRI is supported by the Victorian Government's Operational Infrastructure Support Program.