Altered neural activity in brain cough suppression networks in cigarette smokers
Ayaka Ando, Stuart B Mazzone, Michael J Farrell
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2019
Cough is important for airway defence and studies in healthy animals and humans have revealed multiple brain networks intimately involved in the perception of airway irritation, cough induction and cough suppression. Changes in cough sensitivity and/ or the ability to suppress cough accompany pulmonary pathologies, suggesting a level of plasticity is possible in these central neural circuits. However, little is known about how persistent inputs from the lung might modify the brain processes regulating cough. In the present study, we used human functional brain imaging to investigate the central neural responses that accompany an altered cough sensitivity in cigarette smokers. In non-smokers,..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was supported by grants to S.B. Mazzone and M.J. Farrell from the National Health and Medical Research Council (NHMRC) of Australia (grant 1078943). Funding information for this article has been deposited with the Crossref Funder Registry.