Journal article

Altered neural activity in brain cough suppression networks in cigarette smokers

Ayaka Ando, Stuart B Mazzone, Michael J Farrell

European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2019

Abstract

Cough is important for airway defence and studies in healthy animals and humans have revealed multiple brain networks intimately involved in the perception of airway irritation, cough induction and cough suppression. Changes in cough sensitivity and/ or the ability to suppress cough accompany pulmonary pathologies, suggesting a level of plasticity is possible in these central neural circuits. However, little is known about how persistent inputs from the lung might modify the brain processes regulating cough. In the present study, we used human functional brain imaging to investigate the central neural responses that accompany an altered cough sensitivity in cigarette smokers. In non-smokers,..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

This research was supported by grants to S.B. Mazzone and M.J. Farrell from the National Health and Medical Research Council (NHMRC) of Australia (grant 1078943). Funding information for this article has been deposited with the Crossref Funder Registry.