Prevalence of pre-existing dysglycaemia among inpatients with acute coronary syndrome and associations with outcomes
Dinesh C Mahendran, Garry Hamilton, Jeremy Weiss, Leonid Churilov, Jeremy Lew, Kaylyn Khoo, Que Lam, Raymond Robbins, Graeme K Hart, Douglas Johnson, David L Hare, Omar Farouque, Jeffrey D Zajac, Elif I Ekinci
Diabetes Research and Clinical Practice | ELSEVIER IRELAND LTD | Published : 2019
AIMS: We aimed to confirm the hypothesis that dysglycaemia including in the pre-diabetes range affects a majority of patients admitted with acute coronary syndrome (ACS) and is associated with worse outcomes. METHODS: In this prospective observational cohort study, consecutive inpatients aged ≥ 54 years with ACS were uniformly tested and categorised into diabetes (prior diagnosis/ HbA1c ≥ 6.5%, ≥48 mmol/mol), pre-diabetes (HbA1c 5.7-6.4%, 39-47 mmol/mol) and no diabetes (HbA1c ≤ 5.6%, ≤38 mmol/mol) groups. RESULTS: Over two years, 847 consecutive inpatients presented with ACS. 313 (37%) inpatients had diabetes, 312 (37%) had pre-diabetes and 222 (25%) had no diabetes. Diabetes, compared with..View full abstract
The authors are grateful to Peter Davey (Department of Administrative informatics, Austin Health) and Harvey Sutcliffe (Pathology IT Services, Austin Health) for assistance with data retrieval and information technology support. Dr Ekinci was supported by a Viertel Clinical Investigatorship, RACP -JDRF Fellowship and Sir Edward Weary Dunlop Medical Research Foundation and Diabetes Australia Research Program research grants.