Study protocol for a randomised controlled trial of CBT vs antipsychotics vs both in 14-18-year-olds: Managing Adolescent first episode Psychosis: a feasibility study (MAPS)
Melissa Pyle, Matthew R Broome, Emmeline Joyce, Graeme MacLennan, John Norrie, Daniel Freeman, David Fowler, Peter M Haddad, David Shiers, Chris Hollis, Jo Smith, Ashley Liew, Rory E Byrne, Paul French, Sarah Peters, Jemma Hudson, Linda Davies, Richard Emsley, Alison Yung, Max Birchwood Show all
TRIALS | BMC | Published : 2019
BACKGROUND: Adolescent-onset psychosis is associated with more severe symptoms and poorer outcomes than adult-onset psychosis. The National Institute for Clinical Excellence (NICE) recommend that adolescents with first episode psychosis (FEP) should be offered a combination of antipsychotic medication (APs), cognitive behavioural therapy (CBT) and family intervention (FI). The evidence for APs in treating psychosis is limited in adolescents compared to adults. Nevertheless, it indicates that APs can reduce overall symptoms in adolescents but may cause more severe side effects, including cardiovascular and metabolic effects, than in adults. CBT and FI can improve outcomes in adults, but there..View full abstract
Awarded by NIHR HTA programme
MAPS was funded by the NIHR HTA programme (project number 15/31/04) and the final report will be published in Health Technology Assessment. Visit the HTA programme website for further project information. The Sponsor is Greater Manchester Mental Health NHS Foundation Trust, email R&D@gmmh.nhs.uk.