Journal article

Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders

Tamsyn E Van Rheenen, Vanessa Cropley, Birgitte Fagerlund, Cassandra Wannan, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Andrew Zalesky, Chad A Bousman, Christos Pantelis

Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2020

Abstract

BACKGROUND: In schizophrenia, relative stability in the magnitude of cognitive deficits across age and illness duration is inconsistent with the evidence of accelerated deterioration in brain regions known to support these functions. These discrepant brain-cognition outcomes may be explained by variability in cognitive reserve (CR), which in neurological disorders has been shown to buffer against brain pathology and minimize its impact on cognitive or clinical indicators of illness. METHODS: Age-related change in fluid reasoning, working memory and frontal brain volume, area and thickness were mapped using regression analysis in 214 individuals with schizophrenia or schizoaffective disorder ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Brain and Behavior Research Foundation (NARSAD)


Awarded by National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF)


Awarded by NHMRC


Funding Acknowledgements

Dr Van Rheenen was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (1088785). Dr Cropley was supported by a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660), and a University of Melbourne Faculty of Medicine, Dentistry, and Health Sciences Research Fellowship. Dr Zalesky was supported by an NHMRC Fellowship (1047648). Dr Bousman was supported by an NHMRC Career Development Fellowship (1127700). Prof Shannon Weickert is funded by the NSW Ministry of Health, Office of Health and Medical Research. CSW is a recipient of a National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF) (#1117079). Professor Pantelis was supported by an NHMRC Senior Principal Research Fellowship (628386 and 1105825) and by a NARSAD Distinguished Investigator Award. Data for this study were provided by the ASRB, which is supported by the NHMRC (enabling grant 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute. The authors thank the chief investigators and manager of the ASRB: Carr V, Schall U, Scott R, Jablensky A, Mowry B, Michie P, Catts S, Henskens F, Pantelis C and Loughland C. None of the funding sources played any role in the study design; in the collection, analysis or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication