Journal article

pQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Jennifer Vlok, Peter J Simm, Kate Lycett, Susan A Clifford, Anneke C Grobler, Katherine Lange, Najmi Ismail, William Osborn, Melissa Wake

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVES: To describe the epidemiology and concordance of bone health in a population-based sample of Australian parent-child dyads at child age 11-12 years. DESIGN: Population-based cross-sectional study (the Child Health CheckPoint) nested between waves 6 and 7 of the Longitudinal Study of Australian Children (LSAC). SETTING: Assessment centres in seven cities around Australia, February 2015-March 2016. PARTICIPANTS: of all participating CheckPoint families (n=1874), bone data were available for 1222 dyads (1271 children, 50% girls; 1250 parents, 86% mothers). OUTCOME MEASURES: Peripheral quantitative CT (pQCT) of the non-dominant leg scanned at the 4% (distal) and 66% (mid-calf) tibial ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Awarded by National Heart Foundation of Australia Postdoctoral Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grants 1041352, 1109355), The Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute (MCRI), The University of Melbourne, the National Heart Foundation of Australia (100660) and Financial Markets Foundation for Children (2014-055, 2016-310). MW was supported by Cure Kids, New Zealand. The following authors were supported by the NHMRC: Senior Research Fellowship to MW (1046518) and Early Career Fellowship to KLy (1091124). KLy was supported by a National Heart Foundation of Australia Postdoctoral Fellowship (101239). The MCRI administered the research grants for the study and provided infrastructural support (IT and biospecimen management) to its staff and the study, but played no role in the conduct or analysis of the trial. DSS played a role in study design; however, no other funding bodies had a role in the study design and conduct; data collection, management, analysis and interpretation; preparation, review or approval of the manuscript and decision to submit the manuscript for publication. Research at the MCRI is supported by the Victorian Government's Operational Infrastructure Support Program.