Journal article

Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Thien Nguyen Minh, Kate Lycett, Regan Vryer, David P Burgner, Sarath Ranganathan, Anneke C Grobler, Melissa Wake, Richard Saffery

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVES: To (1) describe the epidemiology of child and adult telomere length, and (2) investigate parent-child telomere length concordance. DESIGN: Population-based cross-sectional study within the Longitudinal Study of Australian Children. SETTING: Assessment centres in seven major Australian cities and eight selected regional towns; February 2015 to March 2016. PARTICIPANTS: Of 1874 participating families, telomere data were available for analysis for 1206 children and 1343 parents, of whom 1143 were parent-child pairs. There were 589 boys and 617 girls; 175 fathers and 1168 mothers. OUTCOME MEASURES: Relative telomere length (T/S ratio), calculated by comparing telomeric DNA (T) level ..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by National Health and Medical Research Council Postgraduate Scholarship


Awarded by National Health and Medical Research Council Fellowship


Awarded by Honorary Future Leader Fellowship of the National Heart Foundation of Australia


Awarded by National Health and Medical Research Council Early Career Fellowship


Awarded by National Heart Foundation Postdoctoral Fellowship


Awarded by National Health and Medical Research Council Senior Research Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (Project Grants 1041352, 1109355), The Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute (MCRI), the Department of Social Services, the University of Melbourne, the National Heart Foundation of Australia (100660) and the Financial Markets Foundation for Children (2014-055, 2016-310). MTN was supported by a National Health and Medical Research Council Postgraduate Scholarship (1115167). DPB was supported by a National Health and Medical Research Council Fellowship (1064629) and an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (100369). SR was supported by a Murdoch Children's Research Institute Clinician Scientist Award. KL was supported by a National Health and Medical Research Council Early Career Fellowship (1091124) and a National Heart Foundation Postdoctoral Fellowship (101239). RV was supported by an Australian Postgraduate Award. MW was supported by a National Health and Medical Research Council Senior Research Fellowship (1046518) and Cure Kids New Zealand. RS was supported by a National Health and Medical Research Council Senior Research Fellowship (1045161). The Murdoch Children's Research Institute administered the research grants and provided infrastructural support (IT and Biospecimen management) to its staff and the study, but played no role in the conduct or analysis of the trial. The Department of Social Services played a role in study design; however, no other funding bodies had a role in the study design and conduct; data collection, management, analysis, and interpretation; preparation, review or approval of the manuscript and decision to submit the manuscript for publication. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.