Journal article

Vascular function and stiffness: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Freya K Kahn, Melissa Wake, Kate Lycett, Susan Clifford, David P Burgner, Greta Goldsmith, Anneke C Grobler, Katherine Lange, Michael Cheung

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVES: To describe the epidemiology and parent-child concordance of vascular function in a population-based sample of Australian parent-child dyads at child age 11-12 years. DESIGN: Cross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC). SETTING: Assessment centres in seven major Australian cities and eight regional towns or home visits, February 2015-March 2016. PARTICIPANTS: Of all participating CheckPoint families (n=1874), 1840 children (49% girls) and 1802 parents (88% mothers) provided vascular function data. Survey weights and methods were applied to account for LSAC's complex sample design a..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Funding Acknowledgements

, The University of Melbourne This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (project grants 1041352 and 1109355), The Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute (MCRI), The University of Melbourne, the National Heart Foundation of Australia (100660) and the Financial Markets Foundation for Children (2014-055 and 2016-310). The following authors were supported by the NHMRC: Senior Research Fellowships to MW (1046518) and DPB (1064629) and Early Career Fellowship to KLy (1091124). The following authors were supported by the National Heart Foundation of Australia: Honorary Future Leader Fellowship to DPB (100369) and Postdoctoral Fellowship to KLy (101239). MW was supported by Cure Kids New Zealand. The MCRI administered the research grants for the study and provided infrastructural support (information technology and biospecimen management) to its staff and the study, but played no role in the conduct or analysis of the trial. DSS played a role in study design; however, no other funding bodies had a role in the study design and conduct; data collection, management, analysis and interpretation; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication. Research at the MCRI is supported by the Victorian Government's Operational Infrastructure Support Program.