Journal article

Carotid artery intima-media thickness, distensibility and elasticity: population epidemiology and concordance in Australian children aged 11-12 years old and their parents

Richard S Liu, Sophie Dunn, Anneke C Grobler, Katherine Lange, Denise Becker, Greta Goldsmith, John B Carlin, Markus Juonala, Melissa Wake, David P Burgner

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVES: To describe a well-established marker of cardiovascular risk, carotid intima-media thickness (IMT) and related measures (artery distensibility and elasticity) in children aged 11-12 years old and mid-life adults, and examine associations within parent-child dyads. DESIGN: Cross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC). SETTING: Assessment centres in seven Australian major cities and eight selected regional towns, February 2015 to March 2016. PARTICIPANTS: Of all participating CheckPoint families (n=1874), 1489 children (50.0% girls) and 1476 parents (86.8% mothers) with carotid IMT da..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Awarded by National Heart Foundation of Australia Honorary Future Leader Fellowship


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (1041352, 1109355), The Royal Children's Hospital Foundation (2014-241), Murdoch Children's Research Institute (MCRI), The University of Melbourne, National Heart Foundation of Australia (100660), Financial Markets Foundation for Children (2014-055) and the Victorian Deaf Education Institute. Research at the MCRI is supported by the Victorian Government's Operational Infrastructure Support Program. The following authors were supported by the NHMRC: Postgraduate Scholarship (1114567) to RSL, Senior Research Fellowships to MW (1046518) and DPB (1064629). RSL is supported by an Australian Government Research Training Program Scholarship. MJ is supported by the Federal Research Grant of Finland to Turku University Hospital, Finnish Cardiovascular Foundation, Juho Vainio Foundation, Sigrid Juselius Foundation, Maud Kuistila Foundation, the Paulo Foundation and the MCRI (Dame Elizabeth Murdoch Fellowship). MW was supported by Cure Kids, New Zealand. DPB was supported by the National Heart Foundation of Australia Honorary Future Leader Fellowship (100369). Personalfees were received by MW from the Australian Department of Social Services (DSS). MW received grants from NZ Ministry of Business, Innovation and Employment and A Better Start/Cure Kids NZ. The MCRI administered the research grants for the study and provided infrastructural support (IT and biospecimen management) to its staff and the study, but played no role in the conduct or analysis of the trial. DSS played a role in study design; however, no other funding bodies had a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.