The function of lgr5 cells in the gastric antrum does not require fzd7 or myc in vivo

D Flanagan; N Barker; M Ernst; E Vincan; T Phesse

Journal article

The function of lgr5 cells in the gastric antrum does not require fzd7 or myc in vivo

D Flanagan, N Barker, M Ernst, E Vincan, T Phesse

Biomedicines | MDPI | Published : 2019

DOI: 10.3390/BIOMEDICINES7030050

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Abstract

The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining. Stem cells of the intestine and stomach, marked by the cell surface receptor Lgr5, preserve the cellular status-quo of their respective tissues through receipt and integration of multiple cues from the surrounding niche. Wnt signalling is a critical niche component for gastrointestinal stem cells and we have previously shown that the Wnt receptor, Frizzled-7 (Fzd7), is required for gastric homeostasis and the function of Lgr5+ intestinal stem cells. Additionally, we have previously shown a requirement for the Wnt target gene Myc in intestinal homeostasis, regene..

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University of Melbourne Researchers

Elizabeth Vincan Author

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Grants

Awarded by Cardiff University

Funding Acknowledgements

Funding is gratefully acknowledged from the following; National Health and Medical Research Council of Australia (NHMRC, 566679 and APP1099302 awarded to E.V./T.P./N.B.), Melbourne Health project grants (605030 and PG-002 awarded to E.V./T.P./N.B.), Medical Research Council (MR/R026424/1 to T.P.), and Early career researcher grant (GIA-033 awarded to D.F.), Cancer Council of Victoria project grants (CCV, APP1020716 awarded to E.V./T.P./N.B.), CCV Fellowship awarded to D.F. and Cardiff University/CMU Research Fellowship awarded to T.P.