Journal article

The Function of Lgr5( ) Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

Dustin Flanagan, Nick Barker, Matthias Ernst, Elizabeth Vincan, Toby Phesse

BIOMEDICINES | MDPI | Published : 2019

Abstract

The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining. Stem cells of the intestine and stomach, marked by the cell surface receptor Lgr5, preserve the cellular status-quo of their respective tissues through receipt and integration of multiple cues from the surrounding niche. Wnt signalling is a critical niche component for gastrointestinal stem cells and we have previously shown that the Wnt receptor, Frizzled-7 (Fzd7), is required for gastric homeostasis and the function of Lgr5+ intestinal stem cells. Additionally, we have previously shown a requirement for the Wnt target gene Myc in intestinal homeostasis, regene..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Melbourne Health project


Awarded by Medical Research Council


Awarded by Early career researcher grant


Awarded by Cancer Council of Victoria project grants (CCV)


Funding Acknowledgements

Funding is gratefully acknowledged from the following; National Health and Medical Research Council of Australia (NHMRC, 566679 and APP1099302 awarded to E.V./T.P./N.B.), Melbourne Health project grants (605030 and PG-002 awarded to E.V./T.P./N.B.), Medical Research Council (MR/R026424/1 to T.P.), and Early career researcher grant (GIA-033 awarded to D.F.), Cancer Council of Victoria project grants (CCV, APP1020716 awarded to E.V./T.P./N.B.), CCV Fellowship awarded to D.F. and Cardiff University/CMU Research Fellowship awarded to T.P.