Journal article

Neural signatures of conditioning, extinction learning, and extinction recall in posttraumatic stress disorder: a meta-analysis of functional magnetic resonance imaging studies

Benjamin Suarez-Jimenez, Anton Albajes-Eizagirre, Amit Lazarov, Xi Zhu, Ben J Harrison, Joaquim Radua, Yuval Neria, Miquel A Fullana

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2020

Abstract

BACKGROUND: Establishing neurobiological markers of posttraumatic stress disorder (PTSD) is essential to aid in diagnosis and treatment development. Fear processing deficits are central to PTSD, and their neural signatures may be used as such markers. METHODS: Here, we conducted a meta-analysis of seven Pavlovian fear conditioning fMRI studies comparing 156 patients with PTSD and 148 trauma-exposed healthy controls (TEHC) using seed-based d-mapping, to contrast neural correlates of experimental phases, namely conditioning, extinction learning, and extinction recall. RESULTS: Patients with PTSD, as compared to TEHCs, exhibited increased activation in the anterior hippocampus (extending to the..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Mental Health


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by FEDER grant (Spain)


Funding Acknowledgements

We thank the following authors for providing additional data or information in support of the meta-analyses: Slawomira J. Diener, Herta Flor, Antonia N. Kaczkurkin, Kevin S. LaBar, Shmuel Lissek, Rajendra A. Morey, Frauke Nees, and Manon Wicking. Dr Suarez-Jimenez's role in this project is supported by grant T32MH015144 and K01 MH118428-01 from the National Institute of Mental Health. Dr Lazarov's role in this project is supported by grant T32MH020004 from the National Institutes of Mental Health. A/Prof. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (1124472). Dr Radua's role in this project is supported by a 'Miguel Servet' contract from the Carlos III Health Institute, and FEDER grant (Spain; CP14/00041). Dr Neria's role in this project is supported by grants R01MH105355 and R01MH072833 from the National Institute of Mental Health. Also, he is supported by the New York State Psychiatric Institute. Dr Fullana's role in this project was supported by Carlos III Health Institute and FEDER grant (Spain; PI16/00144).