Semiannual Versus Annual Influenza Vaccination in Older Adults in the Tropics: An Observer-blind, Active-comparator-controlled, Randomized Superiority Trial
Barnaby Young, Sapna Sadarangani, Sen Yew Haur, Chee Fu Yung, Ian Barr, John Connolly, Mark Chen, Annelies Wilder-Smith
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2019
BACKGROUND: Antibody titres and vaccine effectiveness decline within 6 months after influenza vaccination in older adults. Biannual vaccination may be necessary to provide year-round protection in the tropics, where influenza circulates throughout the year. METHODS: Tropical Influenza Control Strategies (TROPICS1) was a single-center, 1:1 randomized, observer-blinded, active-comparator-controlled, superiority study in 200 community-resident adults aged ≥65 years. Participants received a standard-dose trivalent inactivated influenza vaccination (IIV3) at enrollment, and either tetanus-diphtheria-pertussis vaccination or IIV3 6 months later. The primary outcome was the proportion of participan..View full abstract
Awarded by National Healthcare Group
Awarded by National Medical Research Council
This work was supported by the National Healthcare Group (thematic grant number NTG/13007), the National Medical Research Council (fellowship 0042/2016 to B. Y.), and a Singapore Infectious Diseases Initiative Fellowship (to B. Y.).