Journal article
Phenotypic responses to a lifestyle intervention do not account for inter-individual variability in glucose tolerance for individuals at high risk of type 2 diabetes
G O'Donoghue, A Kennedy, GS Andersen, B Carr, S Cleary, E Durkan, H Davis, K Færch, P Fitzpatrick, H Kenny, N McCaffrey, J Monedero, E Murphy, J Noone, T Suvitaival, T Thybo, M Wheeler, D Vistisen, JJ Nolan, DJ O'Gorman
Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2019
Abstract
Background: Lifestyle interventions have been shown to delay or prevent the onset of type 2 diabetes among high risk adults. A better understanding of the variability in physiological responses would support the matching of individuals with the best type of intervention in future prevention programmes, in order to optimize risk reduction. The purpose of this study was to determine if phenotypic characteristics at baseline or following a 12 weeks lifestyle intervention could explain the inter-individual variability in change in glucose tolerance in individuals with high risk for type 2 diabetes. Methods: In total, 285 subjects with normal glucose tolerance (NGT, FINDRISC score > 12), impaired..
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Awarded by European Commission
Funding Acknowledgements
This work was supported by the EU FP7 programme project DEXLIFE (Grant agreement #279228).