Journal article
Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes
Gisela Di Venanzio, Ana L Flores-Mireles, Juan J Calix, M Florencia Haurat, Nichollas E Scott, Lauren D Palmer, Robert F Potter, Michael E Hibbing, Laura Friedman, Bin Wang, Gautam Dantas, Eric P Skaar, Scott J Hultgren, Mario F Feldman
NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2019
Abstract
Multidrug resistant (MDR) Acinetobacter baumannii poses a growing threat to global health. Research on Acinetobacter pathogenesis has primarily focused on pneumonia and bloodstream infections, even though one in five A. baumannii strains are isolated from urinary sites. In this study, we highlight the role of A. baumannii as a uropathogen. We develop the first A. baumannii catheter-associated urinary tract infection (CAUTI) murine model using UPAB1, a recent MDR urinary isolate. UPAB1 carries the plasmid pAB5, a member of the family of large conjugative plasmids that represses the type VI secretion system (T6SS) in multiple Acinetobacter strains. pAB5 confers niche specificity, as its carria..
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Awarded by National Institute of Allergy and Infectious Diseases
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Funding Acknowledgements
We thank the imaging laboratory of Molecular Microbiology Department at Washington University in St Louis, especially W. Beatty for EM analysis. We thank to the members of the Feldman lab for critical reading of the manuscript. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (grants T32AI007171-38, R01AI144120 and R01DK051406).