Journal article

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

Gisela Di Venanzio, Ana L Flores-Mireles, Juan J Calix, M Florencia Haurat, Nichollas E Scott, Lauren D Palmer, Robert F Potter, Michael E Hibbing, Laura Friedman, Bin Wang, Gautam Dantas, Eric P Skaar, Scott J Hultgren, Mario F Feldman

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Multidrug resistant (MDR) Acinetobacter baumannii poses a growing threat to global health. Research on Acinetobacter pathogenesis has primarily focused on pneumonia and bloodstream infections, even though one in five A. baumannii strains are isolated from urinary sites. In this study, we highlight the role of A. baumannii as a uropathogen. We develop the first A. baumannii catheter-associated urinary tract infection (CAUTI) murine model using UPAB1, a recent MDR urinary isolate. UPAB1 carries the plasmid pAB5, a member of the family of large conjugative plasmids that represses the type VI secretion system (T6SS) in multiple Acinetobacter strains. pAB5 confers niche specificity, as its carria..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Allergy and Infectious Diseases


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

We thank the imaging laboratory of Molecular Microbiology Department at Washington University in St Louis, especially W. Beatty for EM analysis. We thank to the members of the Feldman lab for critical reading of the manuscript. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (grants T32AI007171-38, R01AI144120 and R01DK051406).