Conference Proceedings
EFFECT OF GLUCOCORTICOIDS ON DAMAGE ACCRUAL IN SLE PATIENTS WITH NO CLINICAL OR SEROLOGICAL DISEASE ACTIVITY
Diane Apostolopoulos, Rangi Kandane-Rathnayake, Worawit Louthrenoo, Shue Fen Luo, Yeong-Jian Wu, Aisha Lateef, Vera Golder, Sargunan Sockalingam, Sandra Navarra, Leonid Zamora, Laniyati Hamijoyo, Yasuhiro Katsumata, Masayoshi Harigai, Madelynn Chan, Sean O'neill, Fiona Goldblatt, Alberta Hoi, Mandana Nikpour, Eric F Morand
ANNALS OF THE RHEUMATIC DISEASES | BMJ PUBLISHING GROUP | Published : 2019
Abstract
Background: : Observational studies have previously found associations between glucocorticoid therapy and irreversible organ damage in SLE. As glucocorticoid use and lupus disease activity are highly concordant, disease activity potentially confounds analysis of the contribution of glucocorticoid use to organ damage. This could be obviated through the study of damage accrual in patients without detectable disease activity. Objectives: We studied whether glucocorticoids contribute to damage accrual in SLE in the absence of disease activity, by analysing the effect of glucocorticoids on SLE damage accrual in patients with no clinical or serological lupus disease activity (SLEDAI-2K=0). Methods..
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