Journal article

A Cross-Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children

Markus Juonala, Susan Ellul, Debbie A Lawlor, Diana L Santos Ferreira, John B Carlin, Michael Cheung, Terence Dwyer, Melissa Wake, Richard Saffery, David P Burgner

Journal of the American Heart Association | WILEY | Published : 2019

Abstract

Background High-throughput nuclear magnetic resonance profiling of circulating metabolites is suggested as an adjunct for cardiovascular risk evaluation. The relationship between metabolites and subclinical atherosclerosis remains unclear, particularly among children. Therefore, we examined the associations of metabolites with carotid intima-media thickness ( cIMT ) and arterial pulse wave velocity ( PWV ). Methods and Results Data from two independent population-based studies was examined; (1) cross-sectional associations with cIMT and PWV in 1178 children (age 11-12 years, 51% female) and 1316 parents (mean age 45 years, 87% female) from the CheckPoint study (Australia); and (2) longitudin..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by Murdoch Children's Research Institute, The University of Melbourne, National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by Wellcome Trust


Awarded by European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant


Awarded by National Institutes of Health


Awarded by European Union


Awarded by UK National Institute of Health Research Senior Investigator


Awarded by National Institute of Health


Funding Acknowledgements

The CheckPoint has been supported to date by the National Health and Medical Research Council of Australia (1041352, 1109355), The Royal Children's Hospital Foundation (2014241), Murdoch Children's Research Institute, The University of Melbourne, National Heart Foundation of Australia (100660), the Australian Department of Social Services, and the Financial Markets Foundation for Children (2014-055: 2016-310).The UK Medical Research Council and the Wellcome Trust (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. The work presented here has been supported by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement 669545 (DevelopObese), the National Institutes of Health (R01 DK10324), and the European Union's Horizon 2020 Research and Innovation Programme under grant agreement 733206 (LifeCycle). Lawlor and Santos Ferreira work in a unit that receives funding from the UK Medical Research Council, and Lawlor is a UK National Institute of Health Research Senior Investigator (MC_UU_00011/6). Lawlor is a National Institute of Health Research Senior Investigator (NF-SI-0166-10196).The following authors were supported by the National Health and Medical Research Council of Australia: Senior Research Fellowships (1046518) to Wake and (1064629) Burgner. Juonala is supported by the Federal Research Grant of Finland to Turku University Hospital, Finnish Cardiovascular Foundation, Juho Vainio Foundation, and the Murdoch Children's Research Institute (Dame Elizabeth Murdoch Fellowship). Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program. The Heart Research Group at Murdoch Children's Research Institute is supported by the Royal Children's Hospital 1000, Royal Children's Hospital Foundation, and Big W. The funding bodies did not play any role in the study. The views expressed in this article are those of the authors and not necessarily any funders or anyone acknowledged.