Journal article

Bone morphogenetic protein signaling in breast cancer progression

Lap Hing Chi, Allan D Burrows, Robin L Anderson

GROWTH FACTORS | TAYLOR & FRANCIS LTD | Published : 2019

Abstract

Breast cancer is the most prevalent type of cancer amongst women worldwide. The mortality rate for patients with early-stage breast cancer has been decreasing, however, the 5-year survival rate for patients with metastatic disease remains poor, currently at 27%. Here, we have reviewed the current understanding of the role of bone morphogenetic protein (BMP) signaling in breast cancer progression, and have highlighted the discordant results that are reported in different studies. We propose that some of these contradictory outcomes may result from signaling through either the canonical or non-canonical pathways in different cell lines and tumors, or from different tumor-stromal interactions t..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This work was supported by a grant from the National Health and Medical Research Council (NHMRC) project grant 1121199 (RLA) and graduate scholarship support from La Trobe University (LHC). RLA has received fellowship support from the National Breast Cancer Foundation of Australia.