Journal article
Boosting of Markers of FcγReceptor Function in Anti-HIV Antibodies During Structured Treatment Interruption
H Billings, BD Wines, WB Dyer, RJ Center, HM Trist, SJ Kent, PM Hogarth
AIDS Research and Human Retroviruses | MARY ANN LIEBERT, INC | Published : 2019
Open access
Abstract
Anti-HIV envelope (Env) antibodies elicit important Fc receptor functions, including FcγRIIIa-mediated natural killer cell killing of opsonized infected targets. How these antibodies evolve during HIV infection and treatment remains poorly understood. We describe changes in anti-HIV Env IgG using longitudinal samples from seroconverter subjects treated soon after infection and later during periods of structured treatment interruption (STI). Our well-validated dimeric rsFcγR binding assays combine effects of opsonizing antibody subclasses, epitopes, and geometries to provide a measure of FcγR (Fcγreceptor)-mediated functionality. IgG1 anti-Env titers diminished rapidly during antiretroviral t..
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Funding Acknowledgements
This work was supported by grants from the Australian Centre for HIV and Hepatitis Virology Research (ACH<SUP>2</SUP>), the National Health and Medical Research Council of Australia, and the Victorian Operational Infrastructure Scheme. The authors gratefully acknowledge the support of the Immuno-virology Research Network of the Australian Centre for HIV and Hepatitis Virology Research.