Boosting of Markers of Fc gamma Receptor Function in Anti-HIV Antibodies During Structured Treatment Interruption
Hugh Billings, Bruce D Wines, Wayne B Dyer, Robert J Center, Halina M Trist, Stephen J Kent, P Mark Hogarth
AIDS RESEARCH AND HUMAN RETROVIRUSES | MARY ANN LIEBERT, INC | Published : 2019
Anti-HIV envelope (Env) antibodies elicit important Fc receptor functions, including FcγRIIIa-mediated natural killer cell killing of opsonized infected targets. How these antibodies evolve during HIV infection and treatment remains poorly understood. We describe changes in anti-HIV Env IgG using longitudinal samples from seroconverter subjects treated soon after infection and later during periods of structured treatment interruption (STI). Our well-validated dimeric rsFcγR binding assays combine effects of opsonizing antibody subclasses, epitopes, and geometries to provide a measure of FcγR (Fcγ receptor)-mediated functionality. IgG1 anti-Env titers diminished rapidly during antiretroviral ..View full abstract
This work was supported by grants from the Australian Centre for HIV and Hepatitis Virology Research (ACH<SUP>2</SUP>), the National Health and Medical Research Council of Australia, and the Victorian Operational Infrastructure Scheme. The authors gratefully acknowledge the support of the Immuno-virology Research Network of the Australian Centre for HIV and Hepatitis Virology Research.