Early menarche is associated with lower adult lung function: A longitudinal cohort study from the first to sixth decade of life
Brittany Campbell, Julie A Simpson, Dinh S Bui, Caroline J Lodge, Adrian J Lowe, Melanie C Matheson, Gayan Bowatte, John A Burgess, Garun S Hamilton, Benedicte Leynaert, Francisco Gomez Real, Paul S Thomas, Graham G Giles, Peter A Frith, David P Johns, Gita Mishra, Judith Garcia-Aymerich, Debbie Jarvis, Michael J Abramson, E Haydn Walters Show all
RESPIROLOGY | WILEY | Published : 2019
BACKGROUND AND OBJECTIVE: Early menarche is increasing in prevalence worldwide, prompting clinical and public health interest on its links with pulmonary function. We aimed to investigate the relationship between early menarche and lung function in middle age. METHODS: The population-based Tasmanian Longitudinal Health Study (born 1961; n = 8583), was initiated in 1968. The 5th Decade follow-up data (mean age: 45 years) included age at menarche and complex lung function testing. The 6th Decade follow-up (age: 53 years) repeated spirometry and gas transfer factor. Multiple linear regression and mediation analyses were performed to determine the association between age at menarche and adult lu..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia under NHMRC project
Awarded by NHMRC European collaborative grant scheme as part of ALEC (Ageing Lungs in European Cohorts - European Union's Horizon 2020 research and innovation programme)
We acknowledge the TAHS study participants and previous investigators. We thank Professor Mark Jenkins, Centre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, a TAHS investigator, but not a co-author of this manuscript, for his assistance with obtaining funds and data collection. We also acknowledge all the respiratory scientists who collected data in the lung function laboratories of Tasmania, Victoria, Queensland and New South Wales; the research interviewers and data entry operators and the organizational roles of Mrs Cathryn Wharton and Dr Desiree Meszaros. Finally, we thank the Archives Office of Tasmania for providing data from the 1968 TAHS questionnaires. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia under NHMRC project grant schemes (299901 and 1021275) and NHMRC European collaborative grant scheme (1101313) as part of ALEC (Ageing Lungs in European Cohorts funded by the European Union's Horizon 2020 research and innovation programme under grant agreement no 633212); The University of Melbourne; Clifford Craig Medical Research Trust of Tasmania; the Victorian, Queensland and Tasmanian Asthma Foundations; The Royal Hobart Hospital; Helen MacPherson Smith Trust; and GlaxoSmithKline. The funding agencies had no direct role in the conduct of the study, the collection, management, statistical analysis and interpretation of the data, preparation or approval of the manuscript. J.A.S., C.J.L., A.J.L. and S.C.D. are funded by NHMRC Fellowships.