Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes

Jeremy L Pinyon; Georg von Jonquieres; Edward N Crawford; Mayryl Duxbury; Amr Al Abed; Nigel H Lovell; Matthias Klugmann; Andrew K Wise; James B Fallon; Robert K Shepherd; Catherine S Birman; Waikong Lai; David McAlpine; Catherine McMahon; Paul M Carter; Ya Lang Enke; James F Patrick; Anne GM Schilder; Corinne Marie; Daniel Scherman; Gary D Housley

Journal article

Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes

Jeremy L Pinyon, Georg von Jonquieres, Edward N Crawford, Mayryl Duxbury, Amr Al Abed, Nigel H Lovell, Matthias Klugmann, Andrew K Wise, James B Fallon, Robert K Shepherd, Catherine S Birman, Waikong Lai, David McAlpine, Catherine McMahon, Paul M Carter, Ya Lang Enke, James F Patrick, Anne GM Schilder, Corinne Marie, Daniel Scherman Show all

Hearing Research | ELSEVIER | Published : 2019

DOI: 10.1016/j.heares.2019.06.002

Abstract

This Review outlines the development of DNA-based therapeutics for treatment of hearing loss, and in particular, considers the potential to utilize the properties of recombinant neurotrophins to improve cochlear auditory (spiral ganglion) neuron survival and repair. This potential to reduce spiral ganglion neuron death and indeed re-grow the auditory nerve fibres has been the subject of considerable pre-clinical evaluation over decades with the view of improving the neural interface with cochlear implants. This provides the context for discussion about the development of a novel means of using cochlear implant electrode arrays for gene electrotransfer. Mesenchymal cells which line the cochle..

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University of Melbourne Researchers

Robert Shepherd Author Medical Bionics Department

Andrew Wise Author Medical Bionics Department

James Fallon Author Medical Bionics Department

Grants

Awarded by Australian Research Council (ARC)

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Supported by funding from the Australian Research Council (ARC), grants (ARC DP151014754, ARC LP0992098, ARC LP140101008), the Garnett Passe and Rodney Williams Memorial Foundation, and the National Health and Medical Research Council (NHMRC) grants APP1091646, APP1122055 and GNT1142910. The research was supported by collaborative research funding from Cochlear Ltd.